Histamine Intolerance
Inability to properly break down histamine, causing various symptoms.
Overview
Histamine intolerance occurs when the body can't break down histamine efficiently, leading to a buildup that causes symptoms similar to allergic reactions. Histamine is both produced in the body and found in many foods. Normally, enzymes (especially DAO and HNMT) break down histamine, but some people have reduced enzyme activity. This causes a variety of symptoms including fatigue, headaches, digestive issues, and skin problems, especially after eating high-histamine foods.
Common Age
Any age; often develops in adulthood
Prevalence
Estimated 1-3% of population
Duration
Chronic but manageable; some improve with gut healing
Common Symptoms
- Headaches and migraines
- Nasal congestion and sneezing
- Hives and skin flushing
- Fatigue
- Digestive problems (bloating, diarrhea, nausea)
- Dizziness
- Heart palpitations or racing heart
- Anxiety
- Difficulty sleeping
- Menstrual irregularities
- Low blood pressure
- Symptoms worsen after high-histamine foods or alcohol
Possible Causes
- DAO enzyme deficiency
- HNMT gene variants
- Gut dysbiosis affecting histamine breakdown
- SIBO
- Leaky gut
- Mast cell activation
- Medications blocking DAO
- Nutrient deficiencies (B6, copper, vitamin C)
- Hormonal fluctuations
- High-histamine diet
Note: These are potential causes. A healthcare provider can help determine the specific cause in your case.
Quick Self-Care Tips
- 1Try a low-histamine diet for 2-4 weeks
- 2Eat fresh foods (histamine increases with aging)
- 3Avoid alcohol, especially wine and beer
- 4Keep a food and symptom diary
- 5Consider DAO supplements before meals
- 6Address underlying gut issues
- 7Ensure adequate B6, vitamin C, copper
- 8Work with knowledgeable practitioner
Disclaimer: These are general wellness suggestions, not medical treatment recommendations. They may help manage symptoms but should not replace professional medical care.
Detailed Treatment & Solutions
1LOW-HISTAMINE DIET
Avoid high-histamine foods: aged cheese, cured meats, fermented foods, alcohol, vinegar, canned fish, leftovers. Eat fresh foods. This is diagnostic and therapeutic.
2DAO ENZYME SUPPLEMENTS
Taking DAO before meals helps break down dietary histamine. Doesn't address body-produced histamine. Available over-the-counter.
3SUPPORT NUTRIENTS
Vitamin B6 is cofactor for DAO. Vitamin C helps degrade histamine. Copper supports DAO function. Ensure adequate intake.
4ADDRESS GUT HEALTH
SIBO, dysbiosis, and leaky gut contribute to histamine issues. Treat underlying gut conditions. Some probiotics help; others produce histamine (avoid).
5IDENTIFY TRIGGERS
Beyond foods, triggers include stress, hormonal changes, medications, environmental allergens. Keep detailed diary. Symptoms often delayed hours.
6MEDICATION REVIEW
Some medications block DAO: NSAIDs, some antidepressants, antihistamines (paradoxically), antibiotics. Discuss alternatives with doctor.
Important: Always consult a healthcare professional before starting any treatment regimen. The solutions above are for educational purposes and may not be suitable for everyone.
Risk Factors
- Genetic variants
- Gut disorders
- Certain medications
- Nutrient deficiencies
Prevention
- Address gut health
- Avoid known triggers
- Fresh food diet
When to See a Doctor
Consult a healthcare provider if you experience any of the following:
- Symptoms significantly affect quality of life
- Severe reactions occur
- You need help with elimination diet
- Symptoms persist despite dietary changes
- To rule out other conditions (allergies, mast cell disorders)
Talk to a Healthcare Provider
If your symptoms are persistent, severe, or concerning, please consult with a qualified healthcare professional for proper evaluation and personalized advice.
Frequently Asked Questions
QIs histamine intolerance the same as allergies?
No. Allergies involve IgE antibodies reacting to specific substances. Histamine intolerance is a metabolic issue where you can't break down histamine efficiently. The symptoms overlap because histamine mediates both. However, allergy tests will be negative in histamine intolerance.
QWill I have to avoid high-histamine foods forever?
Not necessarily. A strict low-histamine diet is usually temporary for diagnosis and symptom relief. Many people can reintroduce some foods after addressing underlying issues (gut health, nutrient deficiencies). You'll likely always have some sensitivity, but it often becomes more manageable.
Related Conditions
Migraine
A neurological condition causing intense, throbbing headaches often with nausea and light sensitivity.
Irritable Bowel Syndrome (IBS)
A common disorder affecting the large intestine, causing cramping, abdominal pain, bloating, gas, and diarrhea or constipation.
Food Allergies
Immune system reaction to certain foods, ranging from mild symptoms to life-threatening anaphylaxis.
SIBO (Small Intestinal Bacterial Overgrowth)
Excess bacteria in the small intestine causing bloating, pain, and malabsorption.
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Medical Disclaimer
The information on this page is for educational purposes only and is not intended as medical advice. It should not be used for self-diagnosis or self-treatment. Always seek the guidance of a qualified healthcare professional with any questions you have regarding a medical condition. If you are experiencing a medical emergency, call your local emergency services immediately.
Information last reviewed: January 2026
This page provides educational information only. It is not medical advice.