Mold Illness (CIRS)
Chronic inflammatory response to mold and water-damaged buildings.
Overview
Mold illness, formally called Chronic Inflammatory Response Syndrome (CIRS), is a multi-system inflammatory condition triggered by exposure to mold and mycotoxins in water-damaged buildings. About 25% of the population has genetic susceptibility (HLA-DR genes) that prevents proper elimination of these biotoxins. This leads to chronic inflammation affecting multiple body systems. Diagnosis and treatment are controversial in mainstream medicine but well-established in functional medicine.
Common Age
Any age with exposure and genetic susceptibility
Prevalence
About 25% are genetically susceptible; prevalence of illness unknown
Duration
Chronic if untreated; months to years for recovery after removal and treatment
Common Symptoms
- Fatigue and weakness
- Cognitive problems ("brain fog")
- Memory and concentration issues
- Headaches
- Light sensitivity
- Sinus congestion
- Shortness of breath
- Joint pain and morning stiffness
- Muscle cramps and aches
- Numbness and tingling
- Vertigo
- Night sweats
- Increased thirst and urination
- Static shocks
- Mood changes
Possible Causes
- Water-damaged buildings
- Mold exposure (Stachybotrys, Aspergillus, Penicillium, etc.)
- Mycotoxins
- Genetic susceptibility (HLA-DR genes)
- Other biotoxins (Lyme, dinoflagellates)
- Weakened detoxification
- Prior illness compromising immunity
Note: These are potential causes. A healthcare provider can help determine the specific cause in your case.
Quick Self-Care Tips
- 1Get out of moldy environment first
- 2Test your home for mold (ERMI test)
- 3Work with CIRS-literate practitioner
- 4Don't remediate yourself—hire professionals
- 5Wash or discard contaminated belongings
- 6Support detoxification
- 7Binders may help (cholestyramine, charcoal)
- 8Be patient—recovery takes time
Disclaimer: These are general wellness suggestions, not medical treatment recommendations. They may help manage symptoms but should not replace professional medical care.
Detailed Treatment & Solutions
1REMOVE FROM EXPOSURE
First and most critical step. Leave water-damaged building. Professional remediation required. Some items must be discarded. Living in clean environment essential for recovery.
2TESTING
Visual Contrast Sensitivity (VCS) test. Inflammatory markers (TGF-beta1, MMP-9, MSH, VIP, etc.). ERMI test for building. HLA-DR genetic testing. Work with experienced practitioner.
3BINDER THERAPY
Cholestyramine (prescription) binds biotoxins in gut. Alternatives: Welchol, activated charcoal, bentonite clay. Taken away from food and medications.
4ADDRESS MARS (Multiple Antibiotic Resistant Staph)
Common colonization in CIRS. Nasal spray protocols. BEG spray or similar.
5SUPPORT RECOVERY
Anti-inflammatory diet. Adequate sleep. Gentle exercise when tolerated. Support detox pathways. VIP nasal spray in later stages.
6REMEDIATION
Professional mold inspection and remediation. HEPA air purifiers. Address water intrusion source. Consider ERMI testing after remediation.
Important: Always consult a healthcare professional before starting any treatment regimen. The solutions above are for educational purposes and may not be suitable for everyone.
Risk Factors
- HLA-DR genetic variants
- Water-damaged building exposure
- Prior biotoxin illness
- Weakened immune system
Prevention
- Avoid water-damaged buildings
- Address water intrusion promptly
- Regular home inspection
When to See a Doctor
Consult a healthcare provider if you experience any of the following:
- Multiple unexplained symptoms affecting quality of life
- Symptoms improved when away from home/work
- Living or working in water-damaged building
- No improvement with standard treatments
- To find CIRS-literate practitioner
Talk to a Healthcare Provider
If your symptoms are persistent, severe, or concerning, please consult with a qualified healthcare professional for proper evaluation and personalized advice.
Frequently Asked Questions
QIs mold illness recognized by mainstream medicine?
It's controversial. Mainstream medicine recognizes mold allergies and severe aspergillosis, but many doctors are skeptical of CIRS. Research is growing. The Shoemaker protocol is evidence-based but not widely known. You may need to find a functional medicine or integrative practitioner familiar with CIRS.
QCan I recover from mold illness?
Yes, most people can recover significantly, but it requires getting out of the moldy environment first—this is non-negotiable. Treatment then addresses accumulated toxins and inflammation. Recovery takes months to years depending on severity and how long exposed. Some have residual sensitivities.
Related Conditions
Chronic Fatigue
Persistent tiredness that doesn't improve with rest and affects daily activities.
Brain Fog
Difficulty thinking clearly, concentrating, or remembering things.
Fibromyalgia
A disorder causing widespread musculoskeletal pain, fatigue, and tender points.
Fibromyalgia
A chronic condition causing widespread pain, fatigue, sleep problems, and cognitive difficulties.
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Medical Disclaimer
The information on this page is for educational purposes only and is not intended as medical advice. It should not be used for self-diagnosis or self-treatment. Always seek the guidance of a qualified healthcare professional with any questions you have regarding a medical condition. If you are experiencing a medical emergency, call your local emergency services immediately.
Information last reviewed: January 2026
This page provides educational information only. It is not medical advice.